Clindamycin Syrup - Je Health

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Monday, January 22, 2018

Clindamycin Syrup

Clindamycin Syrup

Clindamycin Syrup is an antibiotic drug to treat serious infections caused by anaerobic bacteria or susceptible aerobic gram-positive bacteria. Syrup preparations are generally available with 75mg / 5ml Clindamycin, used for children. This drug is a semisynthetic lincosamide group antibiotic that is primarily bacteriostatic.

On medical prescription. One of the available brands is Dalacin C Syrup


Clindamycin is an antibiotic drug used to treat serious infections caused by anaerobic bacteria or susceptible aerobic gram-positive bacteria. These antibiotics are used in respiratory infections, skin and soft tissue infections, gastrointestinal infections, septicemia, gynecological infections, bone and joint infections, oral infections, as well as toxoplasmic encephalitis therapy in patients with AIDS (combination with pyrimethamine). Antibiotics is an option if the patient has a history of penicillin-type antibiotic allergy.

Clindamycin is a semisynthetic lincosamide group antibiotic that is primarily bacteriostatic but may also be bactericidal, depending on the concentration of the drug, the location of the infection, and the infecting organism. The mechanism of action of these antibiotics is by inhibiting the synthesis of bacterial proteins by binding reversibly the 50S ribosomal subunit, thereby blocking the transpeptidation or translocation of susceptible organisms resulting in inhibited cell growth.

Clindamycin is generally used in the form of a salt, which is clindamycin hydrochloride. May be used singly or in combination with Benzoyl peroxide, a compound having a mild keratolytic effect and antimicrobial activity associated with its oxidizing effect. The combination of these 2 active substances is effective for acne (acne vulgaris).

Clindamycin is rapidly absorbed from the gastrointestinal tract approximately 90%, through the skin of about 4-5%, and systemically as an intravaginal preparation of about 5%. Foods can reduce the absorption rate of these antibiotics from the digestive tract.
These antibiotics are widely distributed in body fluids and tissues, including bone. Able to enter the placental barrier and into breast milk.


The use of Clindamycin Syrup is to treat serious infections caused by anaerobic bacteria or susceptible gram-positive aerobic bacteria. Anaerobic bacteria: serious respiratory infections such as emphysema, anaerobic pneumonitis, and lung abscesses, serious skin and soft tissue infections, septicemia, such as peritonitis and intra-abdominal abscess (usually from anaerobic organisms already present in the normal gastrointestinal tract), female pelvic infections and genital tracts such as endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postoperative vaginal cyst infection.
Streptococci Bacteria Streptococci: Serious respiratory infections, serious skin and soft tissue infections. Staphylococci: serious respiratory infections, serious skin and soft-tissue infections.
Pneumococci: Serious respiratory infections.
Clindamycin Syrup can be selected as an alternative medicine for penicillin allergy patients.


Do not be given to patients who have a history of drug allergies Clindamycin hydrochloride or lincomycin.


Here are the side effects of Clindamycin Syrup:

Common side effects of Clindamycin Syrup, eg pseudomembranous colitis, diarrhea, abdominal pain, impaired liver function tests, and maculopapular rash.

Less common side effects include eosinophilia, dysgeusia, hypotension, cardiorespiratory arrest, nausea, vomiting, urticaria, erythema multiforme, polyarthritis, and pruritus.

There are few reports of drug side effects containing Clindamycin in the form of agranulocytosis, leukopenia, neutropenia, thrombocytopenia, anaphylactic reactions, Drug reactions with eoshiphilia and systemic symptoms (DRESS), esophagitis, esophageal ulcers, jaundice, toxic epidermal necrolysis, Steven Johnson syndrome, exfoliative dermatitis, bullous dermatitis, vaginal infections, and Acute Generalized Exanthematous Pustulosis (AGEP).

Potentially fatal side effects: Clostridium difficile-associated diarrhea (CDAD) or pseudomembranous colitis, and toxic epidermal necrolysis.


The things that the patient should consider during the use of Clindamycin Syrup drugs are as follows:
All antibiotic drugs including Clindamycin Syrup cause changes in the normal flora of the colon, which causes Clostridium difficile overgrowth. It is prone to cause diarrhea, from mild diarrhea to fatal colitis. For this reason, the use of Clindamycin Syrup antibiotics should be true for serious cases of established infections. Before using this antibiotic can be considered for using alternative antibiotics eg, erythromycin. If diarrhea occurs avoid the use of diarrhea medication, contact your doctor immediately.

All antibiotics including Clindamycin Syrup should not be used in non-bacterial infections such as most upper respiratory tract infections. Because upper respiratory tract infections are generally caused by viruses, while antibiotics can not kill the virus.

The use of Clindamycin Syrup in patients with a history of gastrointestinal disease, especially colitis should be done with caution.
Consider dose reduction in patients with hepatic or renal impairment, as in these patients the plasma levels increase. If antibiotics are used long-term periodic tests of liver and kidney function.

Use of this antibiotic in elderly patients should be done with caution. Take careful monitoring to observe bowel frequency changes.

Clindamycin Syrup should be used with caution in atopic individuals (indicating an allergic form in which hypersensitivity reactions such as dermatitis or asthma can occur in areas of the body that are not in contact with allergens).

The use of Clindamycin Syrup can lead to overgrowth of nonsusceptible organisms - especially yeasts. If superinfection occurs, contact your doctor.

Because Clindamycin Syrup is not adequately distributed to cerebrospinal fluid, this antibiotic drug should not be used in the treatment of meningitis.

Clindamycin Syrup is excreted in breast milk, therefore its use should consider the importance of the drug to the mother and its adverse effects on the baby. Consult your doctor.

When Clindamycin Syrup is administered to the baby, proper monitoring of the functioning of the organ system is needed.

If an allergic reaction occurs, see your doctor immediately for appropriate treatment.


The FDA (drug and food regulatory agency of the united states) categorizes Clindamycin into Category B with the following explanation:
research on animal reproduction shows no risk to the fetus and no adequate and well-controlled studies in pregnant women / Animal studies have shown adverse effects on the fetus, but adequate and well-controlled studies in pregnant women do not indicate a risk to the fetus at any trimester.
Research on animals can not always be used as a basis for the safe use of drugs against pregnant women. The absence of adequate and well-controlled clinical studies in pregnant women makes the use of Clindamycin Syrup drugs for pregnant women should be consulted first with a doctor.


Clindamycin Syrup interacts with the following medications:

Clindamycin has been shown to have neuromuscular inhibitory properties that may increase the therapeutic effect of other neuromuscular inhibitors (eg atracurium). Therefore, it should be used with caution in patients who use these medications.

In vitro there is antagonism between Clindamycin and erythromycin. Therefore, both of these drugs should not be given simultaneously.
Antagonists against the effects of parasympathomimetic drugs.

Competitively inhibits the effects of macrolide class drugs, ketolide, streptogram, linezolid and chloramphenicol.

Coagulation testing increases (prothrombin / INR antagonist) and / or bleeding with K antagonists (eg warfarin, acenocoumarol, fluindione).


Clindamycin Syrup is given at a dose:
Adult dose

Serious infection: 150-300 mg every 6 hours.
A more serious infection: 300-450 mg every 6 hours.

Dose of child:
Serious infections: 8-16 mg / kg divided into 3-4 x administration.

Drink with a glass of water.

Clindamycin Syrup should only be used to treat bacterial infections. These drugs do not treat viral infections (eg, regular flu).
Treatment should be done as recommended by physician. Passing the dose or not completing the entire therapy, may reduce the effectiveness of treatment and increase the occurrence of potential antibiotic resistance.

Diarrhea is a common problem caused by antibiotics that usually end when antibiotics are stopped. Sometimes after starting treatment with antibiotics, patients may experience diarrhea and bloody chapter (with or without stomach cramps and fever) even up to two months or more after taking the last dose of antibiotics. If this happens, the patient should contact a doctor as soon as possible.

Remove any unused remnants of the Clindamycin Syrup drug when it is no longer needed. Do not take this medication after the expiration date on the label has passed. Expired drugs can cause harmful syndromes that cause damage to the kidneys.

Use the Clindamycin Syrup drug according to the rules. Do not take this drug in greater or lesser amount or longer than recommended.

Do not share the drug with others, even if they have symptoms of the same disease as you.

Store medicine at room temperature. Avoid moisture and heat.

Brand of medicine with Clindamycin active ingredient

In the selection of drugs, the benefits to be obtained should be greater than the risks that the patient may experience. Therefore, the use of Clindamycin Syrup drug should be as recommended.

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